Treatment of Stage II Testicular Cancer

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of stage II testicular cancer depends on whether the cancer is a seminoma or a nonseminoma.

Treatment of seminoma may include the following:

• When the tumor is 5 centimeters or smaller:
  • Surgery to remove the testicle, followed by radiation therapy to lymph nodes in the abdomen and pelvis.
  • Combination chemotherapy.
  • Surgery to remove the testicle and lymph nodes in the abdomen.
• When the tumor is larger than 5 centimeters:
  • Surgery to remove the testicle, followed by combination chemotherapy or radiation therapy to lymph nodes in the abdomen and pelvis, with long-term follow-up.

Treatment of nonseminoma may include the following:

• Surgery to remove the testicle and lymph nodes, with long-term follow-up.
• Surgery to remove the testicle and lymph nodes, followed by combination chemotherapy and long-term follow-up.
• Surgery to remove the testicle, followed by combination chemotherapy and a second surgery if cancer remains, with long-term follow-up.
• Combination chemotherapy before surgery to remove the testicle, for cancer that has spread and is thought to be life-threatening.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.